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| Status |
Public on Apr 06, 2021 |
| Title |
The effects of a novel oral nutritional supplement as compared to standard care on body composition, physical function and skeletal muscle mRNA expression in Dutch older adults with (or at risk of) undernutrition |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
In a randomized controlled trial, 82 older adults (>65y) with (or at risk of) undernutrition (n=82) were randomly allocated to 12 weeks of supplementation with a novel supplement (586 kcal, 22 g protein of which 50% whey and 50% casein, 206 mg ursolic acid, 7 g free BCAAs, 11 µg vitamin D) or standard care (600 kcal, 24g protein of which 100% casein, 4 µg vitamin D). Body weight increased significantly in the 12 weeks, both in the intervention group (+1.6 ± 0.2 kg, p<.0001) and in the standard care group (+1.8 ± 0.2 kg, p<.0001). Gait speed during 4m and 400m tests improved over time in the intervention group, whereas the standard care showed no improvements (time*treatment effects 400m: p=0.038 and 4m: p=0.048). Gene sets related to mitochondrial functioning were strongly upregulated in the participants receiving the intervention product. We showed that a novel oral nutritional supplement improves gait speed in older adults via improvements in mitochondrial functioning.
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| Overall design |
Microarray analysis was performed on pre- and post-treatment skeletal muscle biopsies (m. vastus lateralis) from undernourished older adults.
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| Contributor(s) |
Grootswagers P, Smeets E, Oteng A, de Groot L |
| Citation(s) |
33799307 |
| Submission date |
Aug 27, 2019 |
| Last update date |
Apr 09, 2021 |
| Contact name |
Guido Hooiveld |
| E-mail(s) |
guido.hooiveld@wur.nl
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| Organization name |
Wageningen University
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| Department |
Div. Human Nutrition & Health
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| Lab |
Nutrition, Metabolism & Genomics Group
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| Street address |
HELIX, Stippeneng 4
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| City |
Wageningen |
| ZIP/Postal code |
NL-6708WE |
| Country |
Netherlands |
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| Platforms (1) |
| GPL17692 |
[HuGene-2_1-st] Affymetrix Human Gene 2.1 ST Array [transcript (gene) version] |
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| Samples (42)
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| GSM4047976 |
skeletal muscle, novel oral nutritional supplement, subject 202, pre-intervention |
| GSM4047977 |
skeletal muscle, novel oral nutritional supplement, subject 202, post-intervention |
| GSM4047978 |
skeletal muscle, standard-care nutritional supplement, subject 203, pre-intervention |
| GSM4047979 |
skeletal muscle, standard-care nutritional supplement, subject 203, post-intervention |
| GSM4047980 |
skeletal muscle, standard-care nutritional supplement, subject 205, pre-intervention |
| GSM4047981 |
skeletal muscle, standard-care nutritional supplement, subject 205, post-intervention |
| GSM4047982 |
skeletal muscle, standard-care nutritional supplement, subject 211, pre-intervention |
| GSM4047983 |
skeletal muscle, standard-care nutritional supplement, subject 211, post-intervention |
| GSM4047984 |
skeletal muscle, standard-care nutritional supplement, subject 212, pre-intervention |
| GSM4047985 |
skeletal muscle, standard-care nutritional supplement, subject 212, post-intervention |
| GSM4047986 |
skeletal muscle, novel oral nutritional supplement, subject 214, pre-intervention |
| GSM4047987 |
skeletal muscle, novel oral nutritional supplement, subject 214, post-intervention |
| GSM4047988 |
skeletal muscle, standard-care nutritional supplement, subject 215, pre-intervention |
| GSM4047989 |
skeletal muscle, standard-care nutritional supplement, subject 215, post-intervention |
| GSM4047990 |
skeletal muscle, novel oral nutritional supplement, subject 219, pre-intervention |
| GSM4047991 |
skeletal muscle, novel oral nutritional supplement, subject 219, post-intervention |
| GSM4047992 |
skeletal muscle, novel oral nutritional supplement, subject 231, pre-intervention |
| GSM4047993 |
skeletal muscle, novel oral nutritional supplement, subject 231, post-intervention |
| GSM4047994 |
skeletal muscle, standard-care nutritional supplement, subject 238, pre-intervention |
| GSM4047995 |
skeletal muscle, standard-care nutritional supplement, subject 238, post-intervention |
| GSM4047996 |
skeletal muscle, standard-care nutritional supplement, subject 243, pre-intervention |
| GSM4047997 |
skeletal muscle, standard-care nutritional supplement, subject 243, post-intervention |
| GSM4047998 |
skeletal muscle, standard-care nutritional supplement, subject 245, pre-intervention |
| GSM4047999 |
skeletal muscle, standard-care nutritional supplement, subject 245, post-intervention |
| GSM4048000 |
skeletal muscle, standard-care nutritional supplement, subject 250, pre-intervention |
| GSM4048001 |
skeletal muscle, standard-care nutritional supplement, subject 250, post-intervention |
| GSM4048002 |
skeletal muscle, standard-care nutritional supplement, subject 252, pre-intervention |
| GSM4048003 |
skeletal muscle, standard-care nutritional supplement, subject 252, post-intervention |
| GSM4048004 |
skeletal muscle, novel oral nutritional supplement, subject 253, pre-intervention |
| GSM4048005 |
skeletal muscle, novel oral nutritional supplement, subject 253, post-intervention |
| GSM4048006 |
skeletal muscle, novel oral nutritional supplement, subject 258, pre-intervention |
| GSM4048007 |
skeletal muscle, novel oral nutritional supplement, subject 258, post-intervention |
| GSM4048008 |
skeletal muscle, standard-care nutritional supplement, subject 259, pre-intervention |
| GSM4048009 |
skeletal muscle, standard-care nutritional supplement, subject 259, post-intervention |
| GSM4048010 |
skeletal muscle, standard-care nutritional supplement, subject 261, pre-intervention |
| GSM4048011 |
skeletal muscle, standard-care nutritional supplement, subject 261, post-intervention |
| GSM4048012 |
skeletal muscle, novel oral nutritional supplement, subject 264, pre-intervention |
| GSM4048013 |
skeletal muscle, novel oral nutritional supplement, subject 264, post-intervention |
| GSM4048014 |
skeletal muscle, standard-care nutritional supplement, subject 265, pre-intervention |
| GSM4048015 |
skeletal muscle, standard-care nutritional supplement, subject 265, post-intervention |
| GSM4048016 |
skeletal muscle, novel oral nutritional supplement, subject 266, pre-intervention |
| GSM4048017 |
skeletal muscle, novel oral nutritional supplement, subject 266, post-intervention |
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| Relations |
| BioProject |
PRJNA562474 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE136395_RAW.tar |
191.2 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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