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Series GSE36031 Query DataSets for GSE36031
Status Public on Nov 21, 2013
Title Adipocyte XBP1s regulates systemic insulin sensitivity by modulating adiponectin multimerization
Organism Mus musculus
Experiment type Expression profiling by array
Summary The physiological role of the spliced form of X-box-binding protein 1 (XBP1s), a key transcription factor of the endoplasmic reticulum (ER) stress response, in adipose tissue remains largely unknown. Here we show that overexpression of XBP1s promotes adiponectin multimerization in adipocytes, thereby regulating systemic glucose homeostasis. Ectopic expression of XBP1s in adipocytes improves glucose tolerance and insulin sensitivity in both lean and obese (ob/ob) mice. The beneficial effect of adipocyte XBP1s on glucose homeostasis is associated with elevated serum levels of HMW adiponectin and indeed, is adiponectin dependent. Mechanistically, XBP1s promotes adiponectin multimerization rather than activating its transcription likely through a direct regulation of the expression of several ER-chaperones involved in adiponectin maturation, including Grp78, Pdia6, ERp44 and DsbA-L. Thus, we conclude that XBP1s is an important regulator of adiponectin multimerization, which may lead to a new therapeutic approach for the treatment of type 2 diabetes and hypoadiponectinemia.
 
Overall design Epididymal adipose tissue from wild type and XBP1-overexpressing mice was subjected to gene expression profiling.
 
Contributor(s) Sha H, Yang L, Wang A, Liu F, Kersten S, Qi L
Citation(s) 24241534
Submission date Feb 23, 2012
Last update date Mar 04, 2019
Contact name Guido Hooiveld
E-mail(s) guido.hooiveld@wur.nl
Organization name Wageningen University
Department Div. Human Nutrition & Health
Lab Nutrition, Metabolism & Genomics Group
Street address HELIX, Stippeneng 4
City Wageningen
ZIP/Postal code NL-6708WE
Country Netherlands
 
Platforms (1)
GPL6246 [MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version]
Samples (7)
GSM879457 WAT_WT_rep1
GSM879458 WAT_WT_rep2
GSM879459 WAT_WT_rep3
Relations
BioProject PRJNA151747

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE36031_RAW.tar 25.1 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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