Intake of Total and Subgroups of Fat Minimally Affect the Associations between Selected Single Nucleotide Polymorphisms in the PPARγ Pathway and Changes in Anthropometry among European Adults from Cohorts of the DiOGenes Study123
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This work was performed as a part of the research program of Gene-diet interactions in obesity (GENDINOB). GENDINOB is supported by the Danish Council for Strategic Research grant 09-067111.
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Author disclosures: SC Larsen, L A¨ ngquist, JN Østergaard, TS Ahluwalia, KS Vimaleswaran, N Roswall, LM Mortensen, BM Nielsen, A Tjønneland, NJ Wareham, D Palli, G Masala, WHM Saris, DL van der A, JMA Boer, EJM Feskens, H Boeing, MU Jakobsen, RJF Loos, TIA Sørensen, and K Overvad, no conflicts of interest.
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Supplemental Figure 1 and Supplemental Tables 1–12 are available from the “Online Supporting Material” link in the online posting of the article and from the same link in the online table of contents at http://jn.nutrition.org.
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These authors contributed equally to the work.
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Abbreviations used: BW, body weight; CEBPB, CCAAT/enhancer binding protein β gene; DiOGenes, European Diet, Obesity and Genes; EPIC, European Prospective Investigation into Cancer and Nutrition; NCBI, National Center for Biotechnology Information; PCK2, phosphoenolpyruvate carboxykinase γ gene; PPARGγ, peroxisome proliferator-activated receptor γ gene; PPARγ, peroxisome proliferator-activated receptor γ; SNP, single nucleotide polymorphism; SREBF1, sterol regulatory element-binding transcription factor 1 gene; WC, waist circumference; WCBMI, WC adjusted for ΔMI; ΔBW, annual change in body weight; ΔWC, annual change in waist circumference; ΔWCBMI, annual change in waist circumference adjusted for BMI.