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Status |
Public on Aug 10, 2018 |
Title |
Circadian misalignment induces fatty acid metabolism gene profiles and induces insulin resistance in human skeletal muscle. |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by array
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Summary |
Circadian misalignment, such as in shift work, has been associated with obesity and type 2 diabetes, however, direct effects of circadian misalignment on skeletal muscle insulin sensitivity and muscle molecular circadian clock have never been investigated in humans. Here we investigated insulin sensitivity and muscle metabolism in fourteen healthy young lean men (age 22.4 ± 2.8 years; BMI 22.3 ± 2.1 kg/m2 [mean ± SD]) after a 3-day control protocol and a 3.5-day misalignment protocol induced by a 12-h rapid shift of the behavioral cycle. We show that circadian misalignment results in a significant decrease in peripheral insulin sensitivity due to a reduced skeletal muscle non-oxidative glucose disposal (Rate of disappearance: 23.7 ± 2.4 vs. 18.4 ± 1.4 mg/kg/min; control vs. misalignment; p=0.024). Fasting glucose and FFA levels as well as sleeping metabolic rate were higher during circadian misalignment. Molecular analysis of skeletal muscle biopsies revealed that the molecular circadian clock was not aligned to the new behavourial rhythm, and microarray analysis revealed the human PPAR pathway as a key player in the disturbed energy metabolism upon circadian misallignement. Our findings may provide a mechanism underlying the increased risk of type 2 diabetes among shift workers.
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Overall design |
Microarray analysis was performed on skeletal muscle biopsies (m. vastus lateralis) from healthy lean young men in a circadian misalignment study.
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Contributor(s) |
Wefers J, van Moorsel D, Hansen J, Hooiveld GJ, Kersten S, Schrauwen P |
Citation(s) |
29987027 |
Submission date |
Nov 13, 2017 |
Last update date |
Aug 12, 2018 |
Contact name |
Guido Hooiveld |
E-mail(s) |
guido.hooiveld@wur.nl
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Organization name |
Wageningen University
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Department |
Div. Human Nutrition & Health
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Lab |
Nutrition, Metabolism & Genomics Group
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Street address |
HELIX, Stippeneng 4
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City |
Wageningen |
ZIP/Postal code |
NL-6708WE |
Country |
Netherlands |
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Platforms (1) |
GPL17692 |
[HuGene-2_1-st] Affymetrix Human Gene 2.1 ST Array [transcript (gene) version] |
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Samples (47)
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GSM2850460 |
skeletal muscle, circadian aligned intervention, evening (baseline) sample, subject RAS1 |
GSM2850461 |
skeletal muscle, circadian aligned intervention, morning sample, subject RAS1 |
GSM2850462 |
skeletal muscle, circadian misaligned intervention, evening (baseline) sample, subject RAS1 |
GSM2850463 |
skeletal muscle, circadian misaligned intervention, morning sample, subject RAS1 |
GSM2850464 |
skeletal muscle, circadian aligned intervention, evening (baseline) sample, subject RAS2 |
GSM2850465 |
skeletal muscle, circadian aligned intervention, morning sample, subject RAS2 |
GSM2850466 |
skeletal muscle, circadian misaligned intervention, evening (baseline) sample, subject RAS2 |
GSM2850467 |
skeletal muscle, circadian misaligned intervention, morning sample, subject RAS2 |
GSM2850468 |
skeletal muscle, circadian misaligned intervention, evening (baseline) sample, subject RAS6 |
GSM2850469 |
skeletal muscle, circadian misaligned intervention, morning sample, subject RAS6 |
GSM2850470 |
skeletal muscle, circadian aligned intervention, evening (baseline) sample, subject RAS6 |
GSM2850471 |
skeletal muscle, circadian aligned intervention, morning sample, subject RAS6 |
GSM2850472 |
skeletal muscle, circadian misaligned intervention, evening (baseline) sample, subject RAS7 |
GSM2850473 |
skeletal muscle, circadian misaligned intervention, morning sample, subject RAS7 |
GSM2850474 |
skeletal muscle, circadian aligned intervention, evening (baseline) sample, subject RAS7 |
GSM2850475 |
skeletal muscle, circadian aligned intervention, morning sample, subject RAS7 |
GSM2850476 |
skeletal muscle, circadian misaligned intervention, evening (baseline) sample, subject RAS8 |
GSM2850477 |
skeletal muscle, circadian misaligned intervention, morning sample, subject RAS8 |
GSM2850478 |
skeletal muscle, circadian aligned intervention, evening (baseline) sample, subject RAS8 |
GSM2850479 |
skeletal muscle, circadian aligned intervention, morning sample, subject RAS8 |
GSM2850480 |
skeletal muscle, circadian aligned intervention, evening (baseline) sample, subject RAS9 |
GSM2850481 |
skeletal muscle, circadian aligned intervention, morning sample, subject RAS9 |
GSM2850482 |
skeletal muscle, circadian misaligned intervention, morning sample, subject RAS9 |
GSM2850483 |
skeletal muscle, circadian aligned intervention, evening (baseline) sample, subject RAS10 |
GSM2850484 |
skeletal muscle, circadian aligned intervention, morning sample, subject RAS10 |
GSM2850485 |
skeletal muscle, circadian misaligned intervention, evening (baseline) sample, subject RAS10 |
GSM2850486 |
skeletal muscle, circadian misaligned intervention, morning sample, subject RAS10 |
GSM2850487 |
skeletal muscle, circadian misaligned intervention, evening (baseline) sample, subject RAS13 |
GSM2850488 |
skeletal muscle, circadian misaligned intervention, morning sample, subject RAS13 |
GSM2850489 |
skeletal muscle, circadian aligned intervention, evening (baseline) sample, subject RAS13 |
GSM2850490 |
skeletal muscle, circadian aligned intervention, morning sample, subject RAS13 |
GSM2850491 |
skeletal muscle, circadian aligned intervention, evening (baseline) sample, subject RAS14 |
GSM2850492 |
skeletal muscle, circadian aligned intervention, morning sample, subject RAS14 |
GSM2850493 |
skeletal muscle, circadian misaligned intervention, evening (baseline) sample, subject RAS14 |
GSM2850494 |
skeletal muscle, circadian misaligned intervention, morning sample, subject RAS14 |
GSM2850495 |
skeletal muscle, circadian misaligned intervention, evening (baseline) sample, subject RAS15 |
GSM2850496 |
skeletal muscle, circadian misaligned intervention, morning sample, subject RAS15 |
GSM2850497 |
skeletal muscle, circadian aligned intervention, evening (baseline) sample, subject RAS15 |
GSM2850498 |
skeletal muscle, circadian aligned intervention, morning sample, subject RAS15 |
GSM2850499 |
skeletal muscle, circadian aligned intervention, evening (baseline) sample, subject RAS16 |
GSM2850500 |
skeletal muscle, circadian aligned intervention, morning sample, subject RAS16 |
GSM2850501 |
skeletal muscle, circadian misaligned intervention, evening (baseline) sample, subject RAS16 |
GSM2850502 |
skeletal muscle, circadian misaligned intervention, morning sample, subject RAS16 |
GSM2850503 |
skeletal muscle, circadian aligned intervention, evening (baseline) sample, subject RAS17 |
GSM2850504 |
skeletal muscle, circadian aligned intervention, morning sample, subject RAS17 |
GSM2850505 |
skeletal muscle, circadian misaligned intervention, evening (baseline) sample, subject RAS17 |
GSM2850506 |
skeletal muscle, circadian misaligned intervention, morning sample, subject RAS17 |
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Relations |
BioProject |
PRJNA418092 |
Supplementary file |
Size |
Download |
File type/resource |
GSE106800_RAW.tar |
225.7 Mb |
(http)(custom) |
TAR (of CEL) |
Processed data included within Sample table |
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